Galectin-3 Expression Promotes Pulmonary Hypertension Through Multiple Mechanisms

Pulmonary Hypertension is a progressive vascular disease resulting from the tapering of pulmonary arteries causing high arterial blood pressure and ultimately right ventricular failure. A defining characteristic excessive remodeling that includes increased proliferation, fibrosis inflammation. There no outward cure for nor are there interventions effectively impede or reverse remodeling, research over past several decades has sought to identify novel molecular mechanisms target therapeutic benefit. Galectin-3 carbohydrate binding lectin unique its chimeric structure, comprised an N-terminal oligomerization domain C-terminal carbohydrate-recognition domain. regulator modifications in cell behavior contribute aberrant including inflammation, fibrosis, but role poorly understood. In this review, we define summarize specific topics regarding expression development by providing evidence which supports ability influence reactive oxygen species production, NADPH enzyme expression, inflammation all phenomena Hypertension.